Pengaruh Paparan Radiasi Gamma dan Pemberian Ekstrak Kulit Manggis (Garcinia Mangostana) terhadap Kadar SGPT Organ Hepar Mencit (Mus Musculus)

Kadek Ayu Cintya Adelia, Wenti Marlensi Maubana, Yanti Boimau, Kristina Uskenat, Hilary Fridolin Lipikuni

Abstract


Penelitian ini mengkaji pengaruh penggunaan radiasi gamma di bidang kesehatan, salah satunya adalah penggunaan sinar gamma dalam proses radioterapi. Penyerapan energi radiasi ke dalam tubuh dapat menyebabkan munculnya radikal bebas dalam tubuh yang dapat merugikan organ lain di sekitar target penyinaran. Penelitian ini bertujuan untuk mengetahui pengaruh paparan radiasi gamma terhadap hepar mencit dan sifat hepatoprotektif ekstrak kulit manggis(Garcinia mangostana) dalam mengurangi kerusakan sel yang ditimbulkan. Penelitian ini dilakukan dengan memberikan ekstrak kulit manggis 5 dosis varian berbeda ke mencit dan diberi paparan radiasi selama 40 menit dengan dosis total 268 μSv selama 14 hari, kemudian diukur kadar SGPT (serum glutamic pyruvic transaminase) dan jumlah kerusakan sel dari preparathistopatologis. Hasil penelitian menunjukkan kadar SGPT turun menjadi 77,7 U/L dari kadar awal 128,67 U/L. Hal ini membuktikan bahwa ekstrak kulit manggis memiliki sifat hepatoprotektif yang dapat mengurangi kerusakan sel akibat paparan radiasi gamma.


Keywords


Gamma,Hepatoprotektif, Kulit Manggis, Mencit, SGPT

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DOI: https://doi.org/10.37058/diffraction.v2i2.2436

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